Özçelik Zerrin, Avcı Alper, Karacaoğlu İsmail Can, İnce Durhan Banu, Banlı Cesur İlknur, Özçelik Cemal
Department of Pediatric Surgery, Adana City Training and Research Hospital, Adana, Türkiye.
Department of Thoracic Surgery, Çukurova University Faculty of Medicine, Adana, Türkiye.
Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Apr 28;31(2):249-255. doi: 10.5606/tgkdc.dergisi.2023.23269. eCollection 2023 Apr.
This study aims to determine the thoracic surgery techniques, surgical indications, the role and effectiveness of surgical treatment in multimodal treatment applied to pediatric Ewing sarcoma patients.
Between A pril 2004 a nd November 2020, a total of 15 pediatric patients ( 9 males, 6 females; mean age: 10.1±4.5 years; range, 3 to 18 years) who were diagnosed with primary thoracic Ewing sarcoma and operated were retrospectively analyzed. Tumor-related factors and treatment modalities for Ewing sarcoma originating from the chest wall and mediastinum were examined.
The most common complaint was pain in nine patients. While the tumor originated from the ribs in nine patients, it originated from the soft tissue (n=2), mediastinum (n=2), and extra-thoracic tissue (n=2) in six patients. Complete resection was achieved in 10 patients. While neoadjuvant chemotherapy was applied to eight patients, chemotherapy and radiotherapy was applied to 14 and five patients, respectively. Bone marrow transplantation was performed in one patient. The mean follow-up was 54.2±44.9 months. Recurrence was seen in six patients in a mean duration of 17.8±7.4 months.
The most effective treatment for thoracic Ewing sarcoma is complete resection. Multimodal therapy in the form of surgical resection, chemotherapy and/or radiotherapy provides optimal efficacy and the most favorable survival. The follow-up period should be kept short, since recurrences are common.
本研究旨在确定胸外科手术技术、手术适应症，以及手术治疗在小儿尤因肉瘤患者多模式治疗中的作用和效果。
回顾性分析2004年4月至2020年11月期间共15例诊断为原发性胸段尤因肉瘤并接受手术的小儿患者（9例男性，6例女性；平均年龄：10.1±4.5岁；范围3至18岁）。检查了源自胸壁和纵隔的尤因肉瘤的肿瘤相关因素和治疗方式。
9例患者最常见的主诉是疼痛。9例患者肿瘤起源于肋骨，6例患者肿瘤起源于软组织（n = 2）、纵隔（n = 2）和胸外组织（n = 2）。10例患者实现了完全切除。8例患者接受了新辅助化疗，14例和5例患者分别接受了化疗和放疗。1例患者进行了骨髓移植。平均随访时间为54.2±44.9个月。6例患者出现复发，平均复发时间为17.8±7.4个月。
胸段尤因肉瘤最有效的治疗方法是完全切除。手术切除、化疗和/或放疗形式的多模式治疗可提供最佳疗效和最有利的生存率。由于复发常见，随访期应保持较短。
