Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Dev Med Child Neurol. 2014 Jun;56(6):516-21. doi: 10.1111/dmcn.12407. Epub 2014 Feb 17.
Perinatal stroke is the most common cause of hemiplegic cerebral palsy. No standardized early intervention exists despite evidence for a critical time window for activity-dependent plasticity to mould corticospinal tract development in the first few years of life. Intervention during this unique period of plasticity could mitigate the consequences of perinatal stroke to an extent not possible with later intervention, by preserving the normal pattern of development of descending motor pathways. This article outlines the broad range of approaches currently under investigation. Despite significant progress in this area, improved early detection and outcome prediction remain important goals.
围产期卒中是导致偏瘫性脑瘫的最常见原因。尽管有证据表明，在生命最初几年中，活动依赖性可塑性对于塑造皮质脊髓束发育存在关键的时间窗，但目前仍缺乏标准化的早期干预措施。在这个独特的可塑性时期进行干预，可以通过保留下行运动通路的正常发育模式，在一定程度上减轻围产期卒中的后果，而这种程度是后期干预所无法达到的。本文概述了目前正在研究的广泛的方法。尽管在这一领域取得了重大进展，但提高早期检测和结果预测仍然是重要的目标。
