Calgary Pediatric Stroke Program, Alberta Children's Hospital Research Institute, Section of Neurology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Semin Pediatr Neurol. 2013 Jun;20(2):116-26. doi: 10.1016/j.spen.2013.06.004.
The permanent nature of motor deficits is a consistent cornerstone of cerebral palsy definitions. Such pessimism is disheartening to children, families, and researchers alike and may no longer be appropriate for it ignores the fantastic plastic potential of the developing brain. Perinatal stroke is presented as the ideal human model of developmental neuroplasticity following distinct, well-defined, focal perinatal brain injury. Elegant animal models are merging with human applied technology methods, including noninvasive brain stimulation for increasingly sophisticated models of plastic motor development following perinatal stroke. In this article, how potential central therapeutic targets are identified and potentially modulated to enhance motor function within these models is discussed. Also, future directions and emerging clinical trials are reviewed.
运动障碍的永久性是脑瘫定义的一个始终不变的基石。这种悲观情绪令儿童、家庭和研究人员都感到沮丧，而且可能不再合适，因为它忽略了发育中大脑惊人的可塑性潜力。围产期卒中被认为是在明确、明确、局灶性围产期脑损伤后发育神经可塑性的理想人类模型。优雅的动物模型与人类应用技术方法相结合，包括非侵入性脑刺激，用于研究围产期卒中后日益复杂的运动发育可塑性模型。本文讨论了如何确定潜在的中枢治疗靶点，并对其进行潜在的调节，以增强这些模型中的运动功能。还回顾了未来的方向和新兴的临床试验。
