Department of Gastroenterology, Zhongshan Hospital and Center of Evidence-Based Medicine, Fudan University, Shanghai, China.
J Dig Dis. 2014 Mar;15(3):105-7. doi: 10.1111/1751-2980.12112.
Hepatic sinusoidal obstruction syndrome (HSOS), characterized by hepatomegaly, ascites and hyperbilirubinemia, is caused by toxic injury to hepatic sinusoidal endothelial cells. One major etiology of HSOS in China is the intake of products containing pyrrolizidine alkaloids (PA) such as Tusanqi. The manifestations of patients with HSOS are usually non-specific, presenting with abnormal liver function and portal hypertension. Diagnosis of the disease depends mostly on liver histopathology when clinical and imaging data are not sufficient. A history of Tusanqi intake is mostly important for the diagnosis. Due to a lack of effective, evidence-based treatments for HSOS, avoiding the mistaken use of PA-containing products including Tusanqi is important for the prevention of HSOS.
肝窦阻塞综合征（HSOS）的特征为肝肿大、腹水和高胆红素血症，是由肝窦内皮细胞的毒性损伤引起的。在中国，HSOS 的一个主要病因是摄入含有吡咯里西啶生物碱（PA）的产品，如土三七。HSOS 患者的表现通常是非特异性的，表现为肝功能异常和门静脉高压。当临床和影像学数据不足时，该疾病的诊断主要依赖于肝组织病理学。摄入土三七的病史对诊断非常重要。由于缺乏针对 HSOS 的有效、基于证据的治疗方法，避免错误使用含有 PA 的产品，包括土三七，对 HSOS 的预防非常重要。
