Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Atherosclerosis. 2014 Mar;233(1):260-7. doi: 10.1016/j.atherosclerosis.2013.12.037. Epub 2014 Jan 18.
To investigate the relationship between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and chronic kidney disease (CKD).
We used data from 216,007 Japanese adults who participated in a nationwide health checkup program. Men (n = 88,516) and women (n = 127,491) were grouped into quartiles based on their TG/HDL-C levels (<1.26, 1.26-1.98, 1.99-3.18, and >3.18 in men; <0.96, 0.96-1.44, 1.45-2.22, and >2.22 in women). We cross-sectionally assessed the association of TG/HDL-C levels with CKD [defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2) (low eGFR) and/or proteinuria (defined as urinary protein ≥ 1+ on dipstick testing)], low eGFR, and proteinuria.
The prevalence of CKD, low eGFR, and proteinuria increased significantly with elevating quartiles of TG/HDL-C in both genders (all P for trend <0.001). Participants in the highest quartile of TG/HDL-C had a significantly greater risk of CKD than those in the lowest quartile after adjustment for the relevant confounding factors (odds ratio: 1.57, 95% confidence interval: 1.49-1.65 in men; 1.41, 1.34-1.48 in women, respectively). Furthermore, there were significant associations with low eGFR and proteinuria. In stratified analysis, the risk of CKD increased linearly with greater TG/HDL-C levels in participants with and without hypertension, diabetes, and obesity. Moreover, higher TG/HDL-C levels were relevant for CKD, especially in participants with hypertension and diabetes (P for interaction <0.001, respectively).
An elevated TG/HDL-C is associated with the risk of CKD in the Japanese population.
探讨甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）与慢性肾脏病（CKD）的关系。
我们使用了 216007 名日本成年人参加全国健康体检计划的数据。根据 TG/HDL-C 水平，男性（n=88516）和女性（n=127491）分为四组（男性：<1.26、1.26-1.98、1.99-3.18 和 >3.18；女性：<0.96、0.96-1.44、1.45-2.22 和 >2.22）。我们横断面评估了 TG/HDL-C 水平与 CKD[定义为肾小球滤过率（eGFR）<60mL/min/1.73m²（低 eGFR）和/或蛋白尿（尿蛋白≥1+试纸检测）]、低 eGFR 和蛋白尿的关系。
在两性中，随着 TG/HDL-C 四分位升高，CKD、低 eGFR 和蛋白尿的患病率显著增加（所有趋势 P 值均<0.001）。在调整了相关混杂因素后，TG/HDL-C 最高四分位的参与者发生 CKD 的风险明显高于最低四分位的参与者（男性：比值比：1.57，95%置信区间：1.49-1.65；女性：1.41，1.34-1.48）。此外，与低 eGFR 和蛋白尿也存在显著关联。在分层分析中，在有和没有高血压、糖尿病和肥胖的参与者中，CKD 的风险与更高的 TG/HDL-C 水平呈线性相关。此外，更高的 TG/HDL-C 水平与 CKD 相关，尤其是在有高血压和糖尿病的参与者中（交互作用 P 值均<0.001）。
在日本人群中，升高的 TG/HDL-C 与 CKD 风险相关。
