College of Nursing, Mo-Im Kim Nursing Research Institute, Yonsei University, Seoul, Republic of Korea.
Department of Information and Statistics, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Lipids. 2021 Sep;56(5):475-483. doi: 10.1002/lipd.12314. Epub 2021 Jun 5.
Dyslipidemia is nephrotoxic and can result in the development of chronic kidney disease (CKD). The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is well-correlated with insulin resistance and cardiovascular events. The aim of this study is to examine the association between the TG/HDL-C ratio and CKD in Korean adults. This study was retrospectively designed based on the National Health Insurance Service-National Health Screening cohort. Seventy three thousand and fifty-two participants aged between 40 and 79 years old at baseline (2009-2010) were included in the final analyses. The study population was classified into three tertile groups (T , T , and T ) according to the TG/HDL-C ratio by sex. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD were calculated using Cox proportional hazard regression models. The median follow-up duration was 5.9 years. Higher tertile groups of the TG/HDL-C ratio had lower estimated glomerular filtration rates in both sexes. The cumulative incidence of CKD of T , T , and T was 11.89%, 12.90%, and 12.91%, respectively, in men and 10.17%, 10.61%, and 14.87%, respectively, in women (all p values < 0.001). Compared with T of the TG/HDL-C ratio, the HRs (95% CIs) of T and T for CKD were 1.212 (1.118-1.315) and 1.183 (1.087-1.287), respectively, in men and 0.895 (0.806-0.994) and 1.038 (0.937-1.150), respectively, in women after being fully adjusted. Higher TG/HDL-C ratios were positively associated with CKD development in men, while middle levels of TG/HDL ratios reduced the CKD incidence in women.
血脂异常具有肾毒性，并可导致慢性肾脏病（CKD）的发生。甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）的比值（TG/HDL-C 比值）与胰岛素抵抗和心血管事件密切相关。本研究旨在探讨韩国成年人中 TG/HDL-C 比值与 CKD 之间的关系。本研究基于国民健康保险服务-国家健康筛查队列进行回顾性设计。最终分析纳入了 7352 名年龄在 40-79 岁之间的基线（2009-2010 年）参与者。根据 TG/HDL-C 比值，按性别将研究人群分为三个三分位组（T 、T 和 T ）。使用 Cox 比例风险回归模型计算 CKD 的调整后的风险比（HR）和 95%置信区间（CI）。中位随访时间为 5.9 年。在两性中，TG/HDL-C 比值较高的三分位组的估算肾小球滤过率较低。男性中 T 、T 和 T 的 CKD 累积发生率分别为 11.89%、12.90%和 12.91%，女性分别为 10.17%、10.61%和 14.87%（所有 p 值均<0.001）。与 TG/HDL-C 比值的 T 相比，T 和 T 的 CKD 的 HR（95%CI）分别为男性 1.212（1.118-1.315）和 1.183（1.087-1.287），女性 0.895（0.806-0.994）和 1.038（0.937-1.150），经充分调整后。较高的 TG/HDL-C 比值与男性 CKD 发生呈正相关，而中等水平的 TG/HDL-C 比值降低了女性的 CKD 发生率。
