Biozentrum, University of Basel, CH4056 Basel, Switzerland.
Biozentrum, University of Basel, CH4056 Basel, Switzerland.
Cell. 2014 Feb 13;156(4):627-8. doi: 10.1016/j.cell.2014.01.057.
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
mTORC1 主要在溶酶体上被激活。Menon 等人和 Demetriades 等人表明，溶酶体上 mTORC1 的失活取决于其负调节剂肿瘤抑制复合物 TSC1-TSC2 的募集。这些报告强调了细胞内定位在 mTORC1 调节中的重要性。
