Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden.
Placenta. 2014 Mar;35(3):202-6. doi: 10.1016/j.placenta.2014.01.008. Epub 2014 Jan 31.
Our primary aim was to investigate if women with early or late preeclampsia have different placental perfusion compared with normal pregnancies. A secondary aim was to investigate if placental perfusion changes with increasing gestational age in normal pregnancy.
The study population included thirteen women with preeclampsia (five with early and eight with late preeclampsia) and nineteen women with normal pregnancy (ten with early and nine with late pregnancy). Early was defined as <34 weeks and late as ≥ 34 weeks gestation. All women underwent a magnetic resonance imaging (MRI) examination including a diffusion weighted sequence at 1.5 T. The perfusion fraction was calculated.
Women with early preeclampsia had a smaller placental perfusion fraction (p = 0.001) and women with late preeclampsia had a larger placental perfusion fraction (p = 0.011), compared to women with normal pregnancies at the corresponding gestational age. The placental perfusion fraction decreased with increasing gestational age in normal pregnancies (p = 0.001).
Both early and late preeclampsia differ in placental perfusion from normal pregnant women. Observed differences are however in the opposite direction, suggesting differences in pathophysiology. Placental perfusion decreases with increasing gestational age in normal pregnancy.
我们的主要目的是研究早发性或晚发性子痫前期患者的胎盘灌注是否与正常妊娠不同。次要目的是研究正常妊娠中胎盘灌注是否随妊娠周数的增加而变化。
研究人群包括 13 名子痫前期患者（5 名早发性子痫前期，8 名晚发性子痫前期）和 19 名正常妊娠患者（10 名早孕期，9 名晚孕期）。早发性定义为<34 周，晚发性定义为≥34 周。所有女性均接受了 1.5 T 的磁共振成像（MRI）检查，包括扩散加权序列。计算灌注分数。
早发性子痫前期患者的胎盘灌注分数较小（p = 0.001），晚发性子痫前期患者的胎盘灌注分数较大（p = 0.011），与相应妊娠周数的正常妊娠患者相比。正常妊娠中胎盘灌注分数随妊娠周数的增加而降低（p = 0.001）。
早发性和晚发性子痫前期的胎盘灌注与正常孕妇不同。然而，观察到的差异方向相反，提示病理生理学存在差异。正常妊娠中胎盘灌注随妊娠周数的增加而减少。
