Ciciu Elena, Paṣatu-Cornea Ana-Maria, Dumitru Stefania, Petcu Lucian Cristian, Salim Camer, Tuta Liliana-Ana
Nephrology Department, Constanta County Emergency Hospital, 900591 Constanţa, Romania.
Department of Clinical Medical Sciences, Faculty of General Medicine, Ovidius University of Constanţa, 900527 Constanţa, Romania.
Healthcare (Basel). 2023 Jan 29;11(3):381. doi: 10.3390/healthcare11030381.
The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, = 0.009 < α = 0.05). The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition's severity.
子痫前期的病理生理学表现为胎盘缺血和血管生成因子的释放。最近的研究表明，使用可溶性血管内皮生长因子受体-1（sFlt-1）/胎盘生长因子（PIGF）比值来监测血管生成活性更为准确。本研究的目的在于评估sFlt-1/PIGF比值在子痫前期诊断及病情严重程度判定中的临床应用价值。在我们的研究中，采用描述性前瞻性方案，根据孕周和病情严重程度，分析sFlt-1/PIGF比值在子痫前期患者和妊娠期高血压患者中的具体价值。该研究纳入了59例子痫前期患者和25例妊娠期高血压患者。子痫前期孕妇的sFlt-1/PIGF比值平均值为209.2 pg/mL，而在妊娠期高血压组中，sFlt-1/PIGF比值平均值为46.08 pg/mL。子痫前期组与妊娠期高血压组的sFlt-1/PIGF比值差值>67（pg/mL），敏感性为86.44%，特异性为92.00%。早发型亚组重度子痫前期孕妇的sFlt-1/PIGF比值中位数与晚发型亚组相比存在显著差异（分别为307 pg/mL和98 pg/mL，P = 0.009<α = 0.05）。sFlt-1/PIGF比值可能是诊断子痫前期的一种替代方法，并且可以提供有关该病严重程度的数据。
