Dikicier Emre, Karaçaylı Ümit, Dikicier Sibel, Günaydın Yılmaz
Department of Oral and Maxillofacial Surgery, Çorlu Military Hospital, Tekirdağ 59186, Turkey.
Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
J Craniomaxillofac Surg. 2014 Oct;42(7):1106-11. doi: 10.1016/j.jcms.2014.01.039. Epub 2014 Jan 22.
The aim of this study was to evaluate whether zoledronic acid improves post-implant osseointegration in an ovariectomized rat model.
A total of 36 female Wistar rats were subdivided into three groups: control (CTRL), ovariectomized (OVX) and ovariectomized + zoledronic acid (OVX/ZOL). Both OVX and OVX/ZOL groups underwent ovariectomy procedures, while the CTRL group received a sham operation. After a 90-day waiting period following surgery, the OVX/ZOL group received a weekly intravenous injection of 0.04 mg/kg zoledronic acid over a period of 6 weeks. The CTRL and OVX groups received intravenous injections of 0.9% NaCl, and the injections were administered with a dosing schedule that was identical to that of the OVX/ZOL group. After completing the 6-week injection regimen, every group received a titanium implant that was 1.6 mm in diameter by 4 mm in length, which was placed in the proximal metaphysis of the left tibia. All of the rats were sacrificed after 60 days and the tibia bones were harvested and processed for histological evaluation.
The percentage of bone-implant contact (BIC) varied significantly between groups. Histomorphometric analysis demonstrated that BIC was significantly higher in the OVX/ZOL group than in the OVX group.
Systemic zoledronic acid improved tibial titanium implant osseointegration in an oestrogen-deficient rat model.
本研究旨在评估唑来膦酸是否能改善去卵巢大鼠模型植入后的骨整合情况。
总共36只雌性Wistar大鼠被分为三组:对照组(CTRL)、去卵巢组(OVX)和去卵巢 + 唑来膦酸组(OVX/ZOL)。OVX组和OVX/ZOL组均接受去卵巢手术,而CTRL组接受假手术。术后经过90天的等待期,OVX/ZOL组在6周内每周静脉注射0.04 mg/kg唑来膦酸。CTRL组和OVX组静脉注射0.9%氯化钠,注射时间表与OVX/ZOL组相同。完成6周的注射方案后,每组均植入一枚直径1.6 mm、长度4 mm的钛植入物,植入左胫骨近端干骺端。60天后处死所有大鼠,采集胫骨并进行组织学评估。
各组间骨与植入物接触(BIC)百分比差异显著。组织形态计量学分析表明,OVX/ZOL组的BIC显著高于OVX组。
在雌激素缺乏的大鼠模型中,全身应用唑来膦酸可改善胫骨钛植入物的骨整合。