伊洛前列素可维持离体兔主动脉条在缺氧状态下对乙酰胆碱的舒张反应。

Iloprost maintains acetylcholine relaxations of isolated rabbit aortic strips submitted to hypoxia.

作者信息

Türker R K, Demirel E

机构信息

Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey.

出版信息

Pharmacology. 1988;36(3):151-5. doi: 10.1159/000138378.

DOI:10.1159/000138378

PMID:2453069

Abstract

The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine. Exposure of the strips to hypoxia in the medium of Krebs alone for 48 h caused a highly significant decrease in the relaxing effect of acetylcholine without altering that of papaverine. Iloprost (10(-9) mol/l), when added to the incubation medium before hypoxia, prevented the loss of the relaxing effect of acetylcholine in angiotensin II precontracted strips. These results were taken as evidence indicating possible protective activity of iloprost in vascular endothelium.

摘要

在以血管紧张素 II 预收缩的离体兔主动脉条上，研究了伊洛前列素对缺氧的保护活性，观察其对乙酰胆碱舒张作用的影响。仅在 Krebs 培养基中将血管条暴露于缺氧环境 48 小时，会导致乙酰胆碱的舒张作用显著降低，而罂粟碱的舒张作用未改变。在缺氧前将伊洛前列素（10⁻⁹ mol/l）添加到孵育培养基中，可防止血管紧张素 II 预收缩条中乙酰胆碱舒张作用的丧失。这些结果被视为伊洛前列素在血管内皮中可能具有保护活性的证据。