Egemen N, Birler K, Avman N, Türker R K
Department of Neurosurgery, Faculty of Medicine, University of Ankara, Turkey.
Acta Neurochir (Wien). 1988;95(3-4):131-5. doi: 10.1007/BF01790774.
A new stable analogue of prostacyclin, iloprost, was tested on the basilar artery of anaesthetized rabbits constricted by electrical stimulation and intracisternal injection of autologous blood. The vasospasm induced by these stimuli was effectively relieved (about 100%) by topical application of iloprost, a stable analogue of prostacyclin (PGI2), and no constriction occurred on further stimulation within one hour. The mechanisms of the action of iloprost and its possible therapeutic value in subarachnoid haemorrhage are discussed.
一种新的稳定的前列环素类似物伊洛前列素，在经电刺激和脑池内注射自体血液而收缩的麻醉兔的基底动脉上进行了测试。这些刺激所诱导的血管痉挛通过局部应用伊洛前列素（一种稳定的前列环素（PGI2）类似物）得到了有效缓解（约100%），并且在一小时内再次刺激时未出现收缩。本文讨论了伊洛前列素的作用机制及其在蛛网膜下腔出血中可能的治疗价值。
