用杀锥虫二脒处理的大鼠的血浆组胺水平。
Plasma histamine levels in rats treated with trypanocidal diamidines.
作者信息
Steinmann U, Estler C J, Dann O
机构信息
Institute für Pharmakologie und Toxikologie, Universität Erlangen-Nürnberg, BRD.
出版信息
Pharmacology. 1988;36(3):204-9. doi: 10.1159/000138385.
PMID:2453070
Abstract
The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene.
摘要
通过高效液相色谱法（HPLC）和荧光检测法评估了用各种新型杀锥虫双脒和双咪唑啉处理的大鼠血浆中的组胺水平。与喷他脒或二脒那嗪相比，等摩尔剂量（10 μmol/kg）的新型化合物使血浆组胺水平升高的程度要小得多。
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