Departments of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., Wuhan 430030, China.
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Y4332, 2725 Chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
Atherosclerosis. 2014 Apr;233(2):375-380. doi: 10.1016/j.atherosclerosis.2014.01.008. Epub 2014 Jan 19.
To investigate the association between genetic variation in telomerase RNA component (TERC) and leukocyte telomere length (LTL) with risk of coronary heart disease (CHD).
An analysis of LTL was conducted, focusing on two SNPs in 2 community-based cohort populations comprising 3500 Chinese Han individuals. In addition, LTL ratio was determined in a case-control setting involving 4351 participants: 2211 healthy individuals and 2140 CHD patients. The association between LTL and the presence and extent of cardiovascular and cerebrovascular lesions were tested. Results confirmed the association of rs12696304 and rs16847897 with LTL in the Chinese Han population (P=1.63×10(-6) and P=1.44×10(-7), respectively). However, these SNPs confer a moderate risk for CHD but did not achieve significant threshold after multiple corrections. Decreased LTL ratio was associated with CHD (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.02-1.34; P<0.01). In addition, the LTL ratio in CHD patients was related to numbers of vascular disease lesions.
Our results do not support a causal role of LTL for the development of CHD. However, LTL may be related to complex conditions associated with cardiovascular and cerebrovascular disease manifestations.
研究端粒酶 RNA 成分（TERC）和白细胞端粒长度（LTL）的遗传变异与冠心病（CHD）风险之间的关联。
对两个位于两个基于社区的队列人群中的 SNPs 进行了 LTL 分析，该人群由 3500 名汉族个体组成。此外，在一个涉及 4351 名参与者的病例对照研究中确定了 LTL 比值：2211 名健康个体和 2140 名 CHD 患者。测试了 LTL 与心血管和脑血管病变的存在和程度之间的关系。结果证实了 rs12696304 和 rs16847897 与汉族人群中 LTL 的关联（P=1.63×10(-6)和 P=1.44×10(-7)）。然而，这些 SNP 对 CHD 有中度风险，但经过多次校正后未达到显著阈值。LTL 比值降低与 CHD 相关（比值比[OR]，1.13；95%置信区间[CI]，1.02-1.34；P<0.01）。此外，CHD 患者的 LTL 比值与血管疾病病变数量有关。
我们的结果不支持 LTL 对 CHD 发展的因果作用。然而，LTL 可能与与心血管和脑血管疾病表现相关的复杂情况有关。
