Okada K, Oishi K, Yoshida O, Sudo K, Kawase M, Nakayama R
Department of Urology, Faculty of Medicine, Kyoto University, Japan.
Urol Res. 1988;16(2):73-8. doi: 10.1007/BF00261959.
The results of hormonal investigation of effects of an antiandrogen, Oxendolone (OXD), alone or in combination with medroxyprogesterone acetate (MPA), on experimentally induced canine BPH are reported. Seventeen beagle dogs were divided into 5 groups: 2 castrate controls for Group 0, 3 BPH controls for Group 1 which received 3 alpha-androstanediol (3 alpha-A) and estradiol (E2) for one year, and 12 dogs consisting of 3 groups which received 3 alpha-A and E2 for 6 months followed by testosterone propionate (TP) and E2 for another 6 months. The last 3 groups were treated with either 200 mg/week of OXD (Group 3) or OXD + 30 mg/week of MPA (Group 4), and otherwise untreated with these hormones (Group 2, T-E controls). On the blood hormone analysis, both T and 5 alpha-dihydrotestosterone (DHT) were generally lowered in the T-E administered groups (Group 2, 3 and 4) compared to those in Group 1. While MPA significantly decreased these androgen levels, OXD did not influence at all. The concentrations of E2 were similar. Although T content in the prostate did not differ significantly within the experimental groups, DHT was the highest in Group 1 and the lowest in Group 4 and was nearly the same level to Group 0. MPA reduced tissue DHT content but OXD did not. In the receptor assay study, nuclear androgen receptor (AR) content in Group 3 and 4 was significantly lower than that in Group 1. No obvious decrease in nuclear AR content could be seen among the other groups.(ABSTRACT TRUNCATED AT 250 WORDS)
报告了抗雄激素奥生多龙（OXD）单独或与醋酸甲羟孕酮（MPA）联合使用对实验诱导的犬良性前列腺增生（BPH）影响的激素研究结果。17只比格犬分为5组：0组为2只去势对照犬，1组为3只BPH对照犬，接受3α-雄甾二醇（3α-A）和雌二醇（E2）治疗1年，另外12只犬分为3组，先接受3α-A和E2治疗6个月，随后接受丙酸睾酮（TP）和E2治疗6个月。最后3组分别用200mg/周的OXD（3组）或OXD + 30mg/周的MPA（4组）治疗，否则不接受这些激素治疗（2组，T-E对照）。血液激素分析显示，与1组相比，T-E给药组（2、3和4组）的T和5α-双氢睾酮（DHT）普遍降低。虽然MPA显著降低了这些雄激素水平，但OXD没有任何影响。E2的浓度相似。虽然前列腺中的T含量在实验组之间没有显著差异，但DHT在1组中最高，在4组中最低，与0组水平相近。MPA降低了组织DHT含量，但OXD没有。在受体测定研究中，3组和4组的核雄激素受体（AR）含量显著低于1组。其他组之间未观察到核AR含量明显下降。（摘要截短至250字）
