鉴定祖代水貂细胞集落形成（MCF）鼠白血病病毒（MuLV）相关RNA的假定内源性前病毒模板。
Identification of putative endogenous proviral templates for progenitor mink cell focus-forming (MCF) MuLV-related RNAs.
作者信息
Amanuma H, Laigret F, Nishi M, Ikawa Y, Khan A S
机构信息
Laboratory of Gene Technology and Safety, Institute of Physical and Chemical Research, Ibaraki, Japan.
出版信息
Virology. 1988 Jun;164(2):556-61. doi: 10.1016/0042-6822(88)90573-9.
Murine leukemia virus (MuLV)-related RNAs exhibiting different env deletions are believed to participate in the generation of leukemogenic mink cell focus-forming (MCF) viruses. We have cloned an endogenous MuLV provirus from AKR/J mouse DNA, designated as A-2, which may serve as template for the env-deleted E2 MuLV RNA, expressed in GIX+ mice (D.E. Levy et al., J. Virol. 56, 691-700 (1985]. We have also isolated an endogenous MCF-related DNA, A-1, which shared close sequence homology with the 7.2-kb RNA expressed in AKR mice (F. Laigret et al., J. Virol. 62, 376-386 (1988] and sustained an identical env deletion. The data indicate that putative precursor MCF-related RNAs are transcribed from a heterogenous family of env-deleted endogenous MuLV DNAs.
表现出不同env缺失的鼠白血病病毒（MuLV）相关RNA被认为参与了致白血病水貂细胞灶形成（MCF）病毒的产生。我们从AKR/J小鼠DNA中克隆了一种内源性MuLV前病毒，命名为A-2，它可能作为env缺失的E2 MuLV RNA的模板，在GIX+小鼠中表达（D.E. Levy等人，《病毒学杂志》56，691 - 700（1985年））。我们还分离出了一种内源性MCF相关DNA，A-1，它与在AKR小鼠中表达的7.2-kb RNA具有密切的序列同源性（F. Laigret等人，《病毒学杂志》62，376 - 386（1988年）），并且存在相同的env缺失。数据表明，推测的前体MCF相关RNA是从env缺失的内源性MuLV DNA的异源家族转录而来的。
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