Wójcik G, Gieroba Z, Lupa K, Niechaj A
Department of Human Physiology, Medical School, Lublin, Poland.
Arch Int Physiol Biochim. 1987 Nov;95(4):319-27.
Interactions between inhibitions of sympathetic nerve discharge (SND) to consecutive stimulations of A- and C-fibres in the aortic nerve and superficial peroneal (SP) nerve have been studied in rabbits anaesthetized with urethane and chloralose. SND was recorded from the renal nerve. At interval of 10 s following conditioning stimulation of SP nerve the test response of SND to activation of C-fibres (interaction SP-C) amounts to 83.7 +/- 7.5% (means +/- SE) of control. After applying both stimulations to the same SP nerve (interaction SP-SP) the test response of SND is significantly lower amounting to 56.3 +/- 3.9%. Comparable decrease of the effect of conditioning stimulation of one type of afferents on the test response to activation of other type of fibres was observed at interval of 10 s in two other interactions (SP-A and C-A). In seven interactions the conditioning stimulation of one type of fibres had no effect on the test response to stimulation of other type of fibres. This was found in one interaction at interval of 10 s (C-SP), in four interactions at interval of 20 s (SP-A, C-SP, SP-C and C-A) and in two interactions at interval of 40 s (SP-A and SP-C). Conditioning stimulations used in above interactions depressed the test responses to activation of the same type of fibres. It is suggested that the decrease or suppression of the effect of conditioning stimulation of one type of afferents on the test response of SND to activation of other type of fibres is related to disinhibition of this response.
在使用氨基甲酸乙酯和水合氯醛麻醉的家兔中，研究了主动脉神经和腓浅神经（SP）中A纤维和C纤维连续刺激引起的交感神经放电抑制（SND）之间的相互作用。从肾神经记录SND。在对SP神经进行条件刺激后间隔10秒，SND对C纤维激活的测试反应（相互作用SP-C）相当于对照的83.7±7.5%（平均值±标准误）。在对同一SP神经施加两种刺激后（相互作用SP-SP），SND的测试反应显著降低，为56.3±3.9%。在另外两种相互作用（SP-A和C-A）中，在间隔10秒时观察到一种传入纤维的条件刺激对另一种纤维激活的测试反应的影响有类似程度的降低。在七种相互作用中，一种纤维的条件刺激对另一种纤维刺激的测试反应没有影响。在间隔10秒的一种相互作用（C-SP）、间隔20秒的四种相互作用（SP-A、C-SP、SP-C和C-A）以及间隔40秒的两种相互作用（SP-A和SP-C）中发现了这种情况。上述相互作用中使用的条件刺激抑制了对同类型纤维激活的测试反应。有人提出，一种传入纤维的条件刺激对SND对另一种纤维激活的测试反应的影响的降低或抑制与这种反应的去抑制有关。
