一种在体内发挥作用的糖肽对肝细胞细胞周期的体外效应
In vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle.
作者信息
Lombard M N, Nadal C, Monnot M J
机构信息
Institut Curie, Biologie Centre Universitaire, Orsay, France.
出版信息
Cell Tissue Kinet. 1987 Sep;20(5):493-7. doi: 10.1111/j.1365-2184.1987.tb01358.x.
Abstract
A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro. It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).
摘要
一种在体内特异性抑制肝细胞细胞周期的因子，被发现可在体外阻断肝细胞的G1-S期转换。根据其对细胞增殖影响的可逆性判断，在我们的培养条件下它被证明是无毒的。它对成纤维细胞系（3T3）的DNA合成没有活性。
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