Lombard M N, Sotty D, Wdzieczak-Bakala J, Lenfant M
Institut Curie, Centre Universitaire, Orsay, France.
Cell Tissue Kinet. 1990 Mar;23(2):99-103. doi: 10.1111/j.1365-2184.1990.tb01336.x.
The synthetic molecule N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), corresponding to the low molecular weight inhibitory factor preventing in vivo haematopoietic stem cell (CFU-S) entry into DNA synthesis, was tested in two heterologous systems in vivo: adult regenerating rat liver and 10-day-old rat hepatocytes synchronized by an irritating trigger. In both systems, it was shown that doses of 2-8 micrograms kg-1 of tetrapeptide inhibited 50-70% of the hepatocyte G1-S transitions.
合成分子N-乙酰基-丝氨酸-天冬氨酸-赖氨酸-脯氨酸（Ac-SDKP），相当于阻止体内造血干细胞（CFU-S）进入DNA合成的低分子量抑制因子，在两种体内异源系统中进行了测试：成年再生大鼠肝脏和经刺激性触发同步化的10日龄大鼠肝细胞。在这两种系统中均显示，2 - 8微克/千克的四肽剂量可抑制50 - 70%的肝细胞从G1期向S期的转变。
