Vigeh Mohsen, Yokoyama Kazuhito, Matsukawa Takehisa, Shinohara Atsuko, Ohtani Katsumi
Department of Hazard Assessment, National Institute of Occupational Safety and Health, Kanagawa, Japan Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan
Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan.
J Child Neurol. 2014 Oct;29(10):1305-11. doi: 10.1177/0883073813516999. Epub 2014 Feb 13.
The effect of prenatal lead exposure on child development has been a topic of public health concern for decades. To estimate prenatal lead exposure effects on early childhood development, maternal blood (n = 364) and umbilical cord blood (n = 224) samples were collected during pregnancy and at delivery. Mental development was assessed using the Harold Ireton Early Child Development Inventory from 174 children. Maternal whole blood lead levels in the first trimester were significantly higher in children with developmental scores <20% than in those with normal scores (mean ± standard deviation: 6.3 ± 1.9 vs 4.0 ± 2.4 µg/dL, respectively, P = .01). Maternal blood lead levels in the first trimester were also inversely associated with the development scores (r = -0.155, P = .041). Logistic regression analysis showed a significant relationship between increasing maternal blood lead levels in the first trimester with low development scores (odds ratio = 1.74, 95% confidence interval = 1.18-2.57, P = .005). The findings of the present study showed a relatively low level of prenatal lead exposure (mean < 6.5 µg/dL) associated with lower developmental scores in early childhood.
几十年来，产前铅暴露对儿童发育的影响一直是公共卫生关注的话题。为了评估产前铅暴露对儿童早期发育的影响，在孕期和分娩时收集了母亲血液样本（n = 364）和脐带血样本（n = 224）。使用哈罗德·艾雷顿儿童早期发育量表对174名儿童的智力发育进行了评估。发育得分低于20%的儿童，其孕早期母亲全血铅水平显著高于得分正常的儿童（均值±标准差分别为：6.3±1.9与4.0±2.4μg/dL，P = 0.01）。孕早期母亲血铅水平也与发育得分呈负相关（r = -0.155，P = 0.041）。逻辑回归分析显示，孕早期母亲血铅水平升高与低发育得分之间存在显著关系（优势比 = 1.74，95%置信区间 = 1.18 - 2.57，P = 0.005）。本研究结果表明，相对较低水平的产前铅暴露（均值<6.5μg/dL）与儿童早期较低的发育得分相关。
