局部麻醉药全身毒性反应（LAST）——我们难道不该担忧吗？
Local anesthetic systemic toxicity (LAST) - Should we not be concerned?
作者信息
Goyal Rakhee, Shukla R N
机构信息
Classified Specialist (Anaesthesia and Critical Care), Command Hospital (SC), Pune 411040, India.
Senior Advisor & HOD, (Anaesthesia and Critical Care), Command Hospital (SC), Pune 411040, India.
出版信息
Med J Armed Forces India. 2012 Oct;68(4):371-5. doi: 10.1016/j.mjafi.2012.02.011. Epub 2012 Jul 17.
Abstract
Local anesthetics are one of the most commonly used drugs in the field of medicine. Yet little is known about the systemic toxicity that can occur with their overdose. In the last few years, a lot of research has taken place understanding the etiology of the Local anesthetics systemic toxicity (LAST) and the role of lipid emulsion in treating it. There is a need to increase the awareness about LAST and establish a protocol to treat any serious neuro or cardiotoxicity.
摘要
局部麻醉药是医学领域最常用的药物之一。然而，对于其过量使用可能发生的全身毒性却知之甚少。在过去几年中，已经开展了大量研究来了解局部麻醉药全身毒性（LAST）的病因以及脂质乳剂在治疗中的作用。有必要提高对LAST的认识，并制定治疗任何严重神经或心脏毒性的方案。
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