帕金森病的药物遗传学——透过药物作用机制。
Pharmacogenetics of Parkinson's disease - through mechanisms of drug actions.
机构信息
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
出版信息
Curr Genomics. 2013 Dec;14(8):568-77. doi: 10.2174/1389202914666131210212521.
Abstract
In the last years due to development of molecular methods a substantial progress in understanding of genetic associations with drug effects in many clinical disciplines has been observed. The efforts to define the role of genetic polymorphisms in optimizing pharmacotherapy of Parkinson's disease (PD) were also undertaken. So far, some promising genetic loci for PD treatment were determined. In the review pharmacogenetic aspects of levodopa, dopamine agonists and COMT inhibitors are discussed.
摘要
在过去的几年中，由于分子方法的发展，人们在许多临床学科中对药物作用的遗传相关性有了更深入的了解。人们还努力确定遗传多态性在优化帕金森病（PD）药物治疗中的作用。到目前为止，已经确定了一些有希望的与 PD 治疗相关的遗传基因座。在这篇综述中，讨论了左旋多巴、多巴胺激动剂和 COMT 抑制剂的遗传药理学方面。
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本文引用的文献
1
The genetics of Parkinson's disease: progress and therapeutic implications.
Mov Disord. 2013 Jan;28(1):14-23. doi: 10.1002/mds.25249.
2
Tailoring drug therapy based on genotype.
J Pharm Pract. 2012 Aug;25(4):413-6. doi: 10.1177/0897190012448311.
3
Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models.
Neurobiol Dis. 2013 Sep;57:38-46. doi: 10.1016/j.nbd.2012.06.025. Epub 2012 Jul 7.
4
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Mov Disord. 2012 Jan;27(1):132-5. doi: 10.1002/mds.23805. Epub 2011 Nov 14.
5
A two-stage meta-analysis identifies several new loci for Parkinson's disease.
PLoS Genet. 2011 Jun;7(6):e1002142. doi: 10.1371/journal.pgen.1002142. Epub 2011 Jun 30.
6
Racial differences may influence the role of cholecystokinin polymorphisms in Parkinson's disease hallucinations.
Mov Disord. 2011 Aug 1;26(9):1781-2. doi: 10.1002/mds.23655. Epub 2011 Apr 19.
7
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Lancet. 2011 Feb 19;377(9766):641-9. doi: 10.1016/S0140-6736(10)62345-8. Epub 2011 Feb 1.
8
The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial.
Ann Neurol. 2011 Jan;69(1):111-8. doi: 10.1002/ana.22155.
9
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26.
10
The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia.
Acta Neurol Scand. 2011 Feb;123(2):117-21. doi: 10.1111/j.1600-0404.2010.01352.x.
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