School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
Neurobiol Dis. 2013 Sep;57:38-46. doi: 10.1016/j.nbd.2012.06.025. Epub 2012 Jul 7.
Interactions between genetic factors and environmental exposures are thought to be major contributors to the etiology of Parkinson's disease. While such interactions are poorly defined and incompletely understood, recent epidemiological studies have identified specific interactions of potential importance to human PD. In this review, the most current data on gene-environment interactions in PD from human studies are critically discussed. Animal models have also highlighted the importance of genetic susceptibility to toxicant exposure and data of potential relevance to human PD are discussed. Goals and needs for the future of the field are proposed.
遗传因素和环境暴露之间的相互作用被认为是帕金森病发病机制的主要因素。尽管这种相互作用尚未明确且尚未完全理解，但最近的流行病学研究已经确定了对人类 PD 具有重要意义的特定相互作用。在这篇综述中，批判性地讨论了来自人类研究的 PD 中基因-环境相互作用的最新数据。动物模型也强调了对毒物暴露的遗传易感性的重要性，并讨论了与人类 PD 相关的潜在数据。提出了该领域未来的目标和需求。
