Mercan Rıdvan, Turan Aynur, Bitik Berivan, Tufan Abdurrahman, Haznedaroglu Seminur, Goker Berna
a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
b Department of Radiology , Yildirim Beyazit Training and Research Hospital , Etlik, Ankara , Turkey.
Mod Rheumatol. 2016;26(3):458-9. doi: 10.3109/14397595.2014.882221. Epub 2014 Feb 18.
Protracted febrile myalgia syndrome (PFMS) is a very rare but severe manifestation of familial Mediterranean fever (FMF) which is characterized by severe debilitating pain in large muscle groups that may last for several weeks. Colchicine is ineffective and treatment is largely supportive. Demonstration of crucial role of interleukin-1 (IL-1) in the pathogenesis of FMF has increased the use of IL-1 blockers in colchicine resistant or intolerant patients. Herein, we reported successful use of an IL-1 inhibitor, anakinra, in treatment of two patients with PFMS.
持续性发热性肌痛综合征（PFMS）是家族性地中海热（FMF）一种非常罕见但严重的表现形式，其特征是大肌群出现严重的使人衰弱的疼痛，可持续数周。秋水仙碱治疗无效，主要是支持性治疗。白细胞介素-1（IL-1）在FMF发病机制中的关键作用的证实增加了IL-1阻滞剂在对秋水仙碱耐药或不耐受患者中的应用。在此，我们报告了IL-1抑制剂阿那白滞素成功用于治疗两名PFMS患者的情况。
