Fujikawa Keita, Migita Kiyoshi, Tsukada Toshiaki, Kawakami Atsushi, Eguchi Katsumi
Department of Rheumatology, Japan Community Health Care Organization (JCHO), Isahaya General Hospital, Japan.
Intern Med. 2014;53(24):2817-9. doi: 10.2169/internalmedicine.53.2871. Epub 2014 Dec 15.
Protracted febrile myalgia syndrome (PFMS) is a rare manifestation of familial Mediterranean fever characterized by prolonged severe myalgia. We herein describe a case of PFMS with fasciitis on magnetic resonance imaging. The response to corticosteroid therapy was prompt, as is typical for PFMS. An MEFV gene analysis revealed the patient to be homozygous for E148Q and compound heterozygous for P369S-R408Q. This is the first case report of a Japanese patient with PFMS. MRI findings may help to diagnose such cases.
持续性发热性肌痛综合征（PFMS）是家族性地中海热的一种罕见表现，其特征为持续性严重肌痛。我们在此描述一例经磁共振成像显示伴有筋膜炎的PFMS病例。正如PFMS的典型情况一样，患者对皮质类固醇治疗反应迅速。MEFV基因分析显示该患者E148Q位点纯合，P369S-R408Q位点复合杂合。这是首例关于日本PFMS患者的病例报告。MRI检查结果可能有助于诊断此类病例。
