一例用托珠单抗成功治疗的双侧类风湿性胸膜炎病例。
A case of bilateral rheumatoid pleuritis successfully treated with tocilizumab.
作者信息
Ohtsuka Keiko, Takeuchi Kimihiko, Matsushita Masatoshi, Aramaki Tetsuo
机构信息
Departments of Orthopedics and Rheumatology, Isesaki Fukushima Hospital , Otemachi, Isesakishi, Gumma , Japan , Kiryu-shi, Gumma , Japan.
出版信息
Mod Rheumatol. 2014 Nov;24(6):1001-4. doi: 10.3109/14397595.2013.874745. Epub 2014 Feb 18.
The patient was a 77-year-old woman diagnosed as having rheumatoid arthritis (RA) in 1973. She was initiated on infliximab therapy in addition to methotrexate administration in 2009. The therapeutic response decreased after the fifth dose of infliximab, and the patient developed rheumatoid pleuritis due to increased RA disease activity. The therapy was switched from infliximab to tocilizumab, which resulted in amelioration of the arthralgias well as pleuritis. Our results suggest that tocilizumab is an effective treatment alternative for the treatment of rheumatoid pleuritis.
该患者为一名77岁女性，于1973年被诊断患有类风湿关节炎（RA）。2009年，除给予甲氨蝶呤外，开始使用英夫利昔单抗治疗。在英夫利昔单抗第五次给药后治疗反应降低，且由于RA疾病活动增加，患者出现了类风湿性胸膜炎。治疗从英夫利昔单抗换用托珠单抗，这使得关节痛和胸膜炎均得到改善。我们的结果表明，托珠单抗是治疗类风湿性胸膜炎的一种有效替代疗法。
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