Henzen-Logmans S C, Stel H V, van Muijen G N, Mullink H, Meijer C J
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Histopathology. 1988 Apr;12(4):359-72. doi: 10.1111/j.1365-2559.1988.tb01951.x.
The intermediate filament profile of adrenal cortex and its related tumours has been evaluated. Most adrenocortical cells contained cytokeratin 8 and 18 as demonstrated by monoclonal antibodies CAM 5.2, M20, M9 and RGE53. Cytokeratin immunoreactivity was not confined to a functional zone of the adrenal cortex. Only a small number of the adrenocortical cells showed vimentin immunoreactivity. From normal adrenal cortex through adenomas, to carcinomas, there is a progressive decrease or even loss of cytokeratin immunoreactivity and an increase in vimentin immunoreactivity. Aberrant cytokeratin expression was not found in adrenocortical adenomas and carcinomas with the antibodies used. Awareness of the possible absence of cytokeratin immunoreactivity in adrenocortical carcinomas is important whenever antibodies to cytokeratins and vimentin are used for diagnostic purposes in poorly differentiated neoplasms.
已对肾上腺皮质及其相关肿瘤的中间丝形态进行了评估。如单克隆抗体CAM 5.2、M20、M9和RGE53所示，大多数肾上腺皮质细胞含有细胞角蛋白8和18。细胞角蛋白免疫反应性并不局限于肾上腺皮质的功能区。只有少数肾上腺皮质细胞显示波形蛋白免疫反应性。从正常肾上腺皮质到腺瘤，再到癌，细胞角蛋白免疫反应性逐渐降低甚至丧失，波形蛋白免疫反应性增加。在所使用的抗体检测中，肾上腺皮质腺瘤和癌未发现异常细胞角蛋白表达。当使用细胞角蛋白和波形蛋白抗体对低分化肿瘤进行诊断时，意识到肾上腺皮质癌可能不存在细胞角蛋白免疫反应性很重要。
