Menkhorst E, Koga K, Van Sinderen M, Dimitriadis E
Embryo Implantation Laboratory, MIMR-PHI (Prince Henry's Institute of Medical Research) Clayton, PO Box 5152, Clayton 3168, VIC, Australia; Monash University, Clayton, VIC, Australia.
Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.
Placenta. 2014 Apr;35(4):281-5. doi: 10.1016/j.placenta.2014.01.009. Epub 2014 Jan 31.
Galectins regulate many cell functions important for placental development, however, the localization and role of galectin-7 is unknown. We hypothesized galectin-7 would be expressed by the placenta and detected in serum. Galectin-7 immunolocalized to syncytiotrophoblast, extravillous trophoblast and glandular epithelium in 1st trimester placenta/decidua and to syncytiotrophoblast and endothelial cells in term placenta, but in pre-eclamptic placentas endothelial staining was absent. Galectin-7 serum concentration was significantly elevated in women (weeks 10-12 and 17-20) who subsequently developed pre-eclampsia compared to women with healthy pregnancies. Galectin-7 is a promising prospective serum biomarker for pre-eclampsia and likely has important functions in placentation.
半乳糖凝集素调节许多对胎盘发育至关重要的细胞功能，然而，半乳糖凝集素-7的定位和作用尚不清楚。我们推测半乳糖凝集素-7会由胎盘表达并在血清中被检测到。在孕早期胎盘/蜕膜中，半乳糖凝集素-7免疫定位在合体滋养层、绒毛外滋养层和腺上皮，在足月胎盘中定位在合体滋养层和内皮细胞，但在子痫前期胎盘中无内皮细胞染色。与健康妊娠的女性相比，随后发生子痫前期的女性（孕10 - 12周和17 - 20周）血清半乳糖凝集素-7浓度显著升高。半乳糖凝集素-7是一种有前景的子痫前期血清生物标志物，并且可能在胎盘形成中具有重要功能。
