在急性髓系白血病患者的首次诱导化疗期间，侵袭性真菌感染会影响完全缓解的实现和长期生存。
Invasive fungal diseases during first induction chemotherapy affect complete remission achievement and long-term survival of patients with acute myeloid leukemia.
机构信息
Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
出版信息
Leuk Res. 2014 Apr;38(4):469-74. doi: 10.1016/j.leukres.2014.01.007. Epub 2014 Jan 20.
We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% CI 1.71-9.81, p<0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% CI 1.20-2.88, p=0.005) were independent factors associated to OS at 3 years.
我们回顾性地在 logistic 回归模型中评估了在首次诱导化疗期间发生的确诊/疑似侵袭性真菌病 (PP-IFD) 在 198 例急性髓系白血病 (AML) 患者中达到完全缓解 (CR) 和总生存 (OS) 的作用。34 例 (17.2%) 患者发生了 PP-IFD。年龄较小、AML 诊断时的良好表现状态以及未发生 PP-IFD (OR 4.09, 95% CI 1.71-9.81, p<0.0001) 是与 CR 达成相关的独立因素。年龄较小、表现状态良好、有利的遗传风险和未发生 PP-IFD (HR 1.86, 95% CI 1.20-2.88, p=0.005) 是与 3 年 OS 相关的独立因素。
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