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免疫功能低下人群抗真菌管理的现状

The Current State of Antifungal Stewardship in Immunocompromised Populations.

作者信息

Alegria William, Patel Payal K

机构信息

Department of Quality, Patient Safety and Effectiveness, Stanford Health Care, 300 Pasteur Drive, Lane 134 L1C36, Stanford, CA 94305, USA.

Stanford Antimicrobial Safety and Sustainability Program, Stanford, CA 94305, USA.

出版信息

J Fungi (Basel). 2021 Apr 30;7(5):352. doi: 10.3390/jof7050352.

DOI:10.3390/jof7050352
PMID:33946217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8145600/
Abstract

Inappropriate antifungal use is prevalent and can lead to drug-resistant fungi, expose patients to adverse drug events, and increase healthcare costs. While antimicrobial stewardship programs have traditionally focused on antibiotic use, the need for targeted antifungal stewardship (AFS) intervention has garnered interest in recent years. Despite this, data on AFS in immunocompromised patient populations is limited. This paper will review the current state of AFS in this complex population and explore opportunities for multidisciplinary collaboration.

摘要

不恰当的抗真菌药物使用很普遍,可能导致耐药真菌产生,使患者面临药物不良事件,并增加医疗成本。虽然抗菌药物管理计划传统上侧重于抗生素的使用,但近年来,针对性抗真菌药物管理(AFS)干预的必要性已引起关注。尽管如此,关于免疫功能低下患者群体中AFS的数据仍然有限。本文将综述这一复杂人群中AFS的现状,并探讨多学科合作的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/8145600/e34c2a6f97e3/jof-07-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/8145600/e34c2a6f97e3/jof-07-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/8145600/e34c2a6f97e3/jof-07-00352-g001.jpg

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本文引用的文献

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Incidence and Risk Factors for Inappropriate Use of Non-Culture-Based Fungal Assays: Implication for Diagnostic Stewardship.非培养真菌检测方法使用不当的发生率及危险因素:对诊断管理的启示
Open Forum Infect Dis. 2021 Dec 6;9(1):ofab601. doi: 10.1093/ofid/ofab601. eCollection 2022 Jan.
2
Utility of 1,3 β-d-Glucan Assay for Guidance in Antifungal Stewardship Programs for Oncologic Patients and Solid Organ Transplant Recipients.1,3-β-D-葡聚糖检测在肿瘤患者和实体器官移植受者抗真菌管理计划指导中的应用
J Fungi (Basel). 2021 Jan 17;7(1):59. doi: 10.3390/jof7010059.
3
Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium.
Antifungal stewardship: the Latin American experience.
抗真菌药物管理:拉丁美洲的经验
Antimicrob Steward Healthc Epidemiol. 2023 Dec 5;3(1):e217. doi: 10.1017/ash.2023.471. eCollection 2023.
4
Using Behavior Change Theory to Identify Drivers and Barriers for Antifungal Treatment Decisions: A Case Study in a Large Teaching Hospital in the East of England, UK.运用行为改变理论确定抗真菌治疗决策的驱动因素和障碍:英国英格兰东部一家大型教学医院的案例研究
Infect Dis Ther. 2023 May;12(5):1393-1414. doi: 10.1007/s40121-023-00796-z. Epub 2023 May 13.
5
Antifungal stewardship in solid organ transplantation.实体器官移植中的抗真菌药物管理。
Transpl Infect Dis. 2022 Oct;24(5):e13855. doi: 10.1111/tid.13855.
6
Incidence and Risk Factors for Inappropriate Use of Non-Culture-Based Fungal Assays: Implication for Diagnostic Stewardship.非培养真菌检测方法使用不当的发生率及危险因素:对诊断管理的启示
Open Forum Infect Dis. 2021 Dec 6;9(1):ofab601. doi: 10.1093/ofid/ofab601. eCollection 2022 Jan.
抗真菌药物管理核心推荐:真菌病研究组教育和研究联盟的声明。
J Infect Dis. 2020 Aug 5;222(Suppl 3):S175-S198. doi: 10.1093/infdis/jiaa394.
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How can we optimise antifungal use in a solid organ transplant centre? Local epidemiology and antifungal stewardship implementation: A single-centre study.如何在实体器官移植中心优化抗真菌药物的使用?局部流行病学和抗真菌药物管理实施:一项单中心研究。
Mycoses. 2020 Jul;63(7):746-754. doi: 10.1111/myc.13098. Epub 2020 May 18.
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Variability in antifungal stewardship strategies among Society for Healthcare Epidemiology of America (SHEA) Research Network facilities.美国医疗机构流行病学学会(SHEA)研究网络机构之间抗真菌药物管理策略的差异。
Infect Control Hosp Epidemiol. 2020 May;41(5):585-589. doi: 10.1017/ice.2020.76. Epub 2020 Apr 7.
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Hope on the Horizon: Novel Fungal Treatments in Development.曙光在前:正在研发的新型真菌治疗方法
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Efficacy of a "Checklist" Intervention Bundle on the Clinical Outcome of Patients with Candida Bloodstream Infections: A Quasi-Experimental Pre-Post Study.“检查表”干预组合对念珠菌血流感染患者临床结局的疗效:一项前后对照的准实验研究。
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Efficacy and safety of a comprehensive educational antimicrobial stewardship program focused on antifungal use.综合性教育抗菌药物管理计划对抗真菌药物使用的疗效和安全性。
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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.侵袭性真菌病的共识定义修订与更新:来自欧洲癌症研究与治疗组织和真菌病研究组教育与研究联合会。
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