Rollin Michael D H, Rollin Bernard E
Camb Q Healthc Ethics. 2014 Apr;23(2):140-51. doi: 10.1017/S0963180113000674.
Animal models of human disease play a central role in modern biomedical science. Developing animal models for human mental illness presents unique practical and philosophical challenges. In this article we argue that (1) existing animal models of psychiatric disease are not valid, (2) attempts to model syndromes are undermined by current nosology, (3) models of symptoms are rife with circular logic and anthropomorphism, (4) any model must make unjustified assumptions about subjective experience, and (5) any model deemed valid would be inherently unethical, for if an animal adequately models human subjective experience, then there is no morally relevant difference between that animal and a human.
人类疾病的动物模型在现代生物医学科学中发挥着核心作用。开发人类精神疾病的动物模型存在独特的实践和哲学挑战。在本文中，我们认为：（1）现有的精神疾病动物模型是无效的；（2）当前的疾病分类学破坏了对综合征进行建模的尝试；（3）症状模型充斥着循环逻辑和拟人化；（4）任何模型都必须对主观体验做出不合理的假设；（5）任何被认为有效的模型本质上都是不道德的，因为如果一种动物能充分模拟人类的主观体验，那么该动物与人类之间就不存在道德上的相关差异。
