Hastings Cent Rep. 2022 Nov;52 Suppl 2(Suppl 2):S34-S40. doi: 10.1002/hast.1430.
Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human suffering due to autism spectrum disorders, depression, and schizophrenia. These calls, however, typically do not acknowledge, much less address, criticisms of model creation and validation, or concerns about scientific conduct more generally. The ethical justification for the use of nonhuman animals in research depends on the production of benefits to humans based on such research. But the assessment and production of benefits are highly uncertain and rife with both practical and conceptual challenges. This essay provides a general framework for classifying the benefits of biomedical research and then focuses on two factors that directly impact-and threaten-the production of knowledge in research that models neuropsychiatric disorders.
近期关于嵌合研究的报告和论文强调了构建人类神经精神疾病嵌合模型的前景，这有望减轻自闭症谱系障碍、抑郁症和精神分裂症给人类带来的痛苦。然而，这些呼吁通常没有认识到，更不用说解决模型创建和验证的批评，或者更普遍的科学行为的担忧。在研究中使用非人类动物的伦理理由取决于基于此类研究为人类带来的益处。但是，益处的评估和产生具有高度的不确定性，并且存在着实际和概念上的挑战。本文提供了一个分类生物医学研究益处的一般框架，然后重点讨论了两个直接影响和威胁到模拟神经精神疾病的研究中知识产生的因素。
