Kweon Sun-Seog, Shin Min-Ho, Kim Hee-Nam, Kim Soo-Hyun, Kang Ho-Cheol
Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseok-ro, Dong-gu, Gwangju, 501-746, South Korea.
Mol Biol Rep. 2014 Jun;41(6):3793-9. doi: 10.1007/s11033-014-3245-z. Epub 2014 Feb 18.
Korea has the highest incidence of thyroid cancer of any nation. We conducted a population-based, case-control study of the association between the risk of papillary thyroid cancer (PTC) in the Korean population and polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T, glutathione S-transferase class mu (GSTM1), and glutathione S-transferase class theta (GSTT1). The study subjects consisted of 2,194 newly diagnosed PTC cases and 1,669 population-based healthy controls. Odds ratios adjusted by age, sex, body mass index, smoking, drinking, serum thyroid-stimulating hormone level, family history of thyroid cancer, and previous history of thyroid disease, with 95% confidence intervals, were estimated using logistic regression analysis. The frequencies of MTHFR 677TT genotypes, and null genotypes of GSTM1 and GSTT1 were 19.2, 56.8, and 51.4% among PTC cases and 17.4, 54.1, and 50.6% among the controls, respectively. No significant associations between PTC and TT genotypes of MTHFR C677T, null genotypes of GSTM1 and GSTT1, or double-null (GSTM1-GSTT1) genotypes were found. These findings suggest that polymorphisms of the MTHFR C677T, GSTM1 and GSTT1 genotypes do not contribute to the development of PTC susceptibility in the Korean population.
韩国是所有国家中甲状腺癌发病率最高的。我们进行了一项基于人群的病例对照研究，以探讨韩国人群中甲状腺乳头状癌（PTC）风险与亚甲基四氢叶酸还原酶（MTHFR）C677T、谷胱甘肽S-转移酶μ类（GSTM1）和谷胱甘肽S-转移酶θ类（GSTT1）基因多态性之间的关联。研究对象包括2194例新诊断的PTC病例和1669例基于人群的健康对照。使用逻辑回归分析估计经年龄、性别、体重指数、吸烟、饮酒、血清促甲状腺激素水平、甲状腺癌家族史和既往甲状腺疾病史调整后的优势比及95%置信区间。PTC病例中MTHFR 677TT基因型、GSTM1和GSTT1无效基因型的频率分别为19.2%、56.8%和51.4%，对照组中分别为17.4%、54.1%和50.6%。未发现PTC与MTHFR C677T的TT基因型、GSTM1和GSTT1无效基因型或双无效（GSTM1-GSTT1）基因型之间存在显著关联。这些发现表明，MTHFR C677T、GSTM1和GSTT1基因型的多态性对韩国人群中PTC易感性的发展没有影响。
