Iacoangeli Maurizio, Rienzo Alessandro Dı, Colasanti Roberto, Scarpelli Marina, Gladi Maurizio, Alvaro Lorenzo, Nocchi Niccolò, Scerrati Massimo
Università Politecnica delle Marche, Department of Neurosurgery, Ancona, Italy.
Turk Neurosurg. 2014;24(1):86-9. doi: 10.5137/1019-5149.JTN.7237-12.0.
Co-occurrence of different brain tumors is rarely observed, being more frequent in patients affected by genetic syndromes like phacomatoses. Different histological types of intracranial lesions may present at different times in the clinical history of the patient or, more rarely, they may occurr at the same moment. In these last cases, particularly for tumors located in adjacent areas of the brain, diagnostic difficulties may arise. Moreover, even when the correct diagnosis is established, treatment strategy becomes complex and a single staged approach could be ineffective in obtaining successful tumor removal. We report a case of simultaneous sellar-suprasellar craniopharyngioma and intradural clival chordoma, successfully treated by a single staged, extended, fully endoscopic endonasal approach, which required no following adjuvant therapy. We also discuss the potential etiopathogenesis of the two lesions, reviewing the literature.
不同脑肿瘤的同时出现很少见，在患有诸如神经皮肤综合征等遗传综合征的患者中更为常见。不同组织学类型的颅内病变可能在患者的临床病程中不同时间出现，或者更罕见的是，它们可能同时出现。在这些最后一种情况下，特别是对于位于脑相邻区域的肿瘤，可能会出现诊断困难。此外，即使确立了正确的诊断，治疗策略也会变得复杂，单一阶段的方法可能无法成功切除肿瘤。我们报告了一例同时发生的鞍区-鞍上颅咽管瘤和硬膜内斜坡脊索瘤病例，通过单一阶段、扩大的、完全内镜下鼻内入路成功治疗，无需后续辅助治疗。我们还讨论了这两种病变的潜在病因，回顾了相关文献。
