Ugurlu Tugce Toker, Acar Goksemin, Karadag Filiz, Acar Feridun
Pamukkale University, Faculty of Medicine, Department of Psychiatry, Denizli, Turkey.
Turk Neurosurg. 2014;24(1):94-7. doi: 10.5137/1019-5149.JTN.7647-12.0.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson's disease (PD) associated with motor complications of long term L-dopa treatment.
Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation.
We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation. DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle.
丘脑底核（STN）的深部脑刺激（DBS）是治疗与长期左旋多巴治疗相关运动并发症的帕金森病（PD）患者的一种既定疗法。
在此，我们报告两例DBS诱发躁狂发作的病例，重点关注STN刺激的精神不良反应的功能和解剖学相关性。
我们呈现两例因长期左旋多巴治疗出现运动并发症的PD患者，在双侧STN-DBS植入后首次出现伴有精神病症状的躁狂发作。DBS诱发的精神不良反应可能归因于边缘系统连接和STN特异性振荡，或内侧前脑束的刺激。
