SMS 201-995对小鼠生长激素分泌的长期抑制对泌乳的影响。

Effect of chronic suppression of growth hormone secretion, by SMS 201-995 on lactation in mice.

作者信息

Nagasawa H, Koshimizu U, Sakagami N

机构信息

Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.

出版信息

Life Sci. 1988;42(24):2483-8. doi: 10.1016/0024-3205(88)90347-5.

DOI:10.1016/0024-3205(88)90347-5

PMID:2453774

Abstract

The effect of chronic suppression of growth hormone (GH) secretion by SMS 201-995 on lactation was studied in primiparous C3H/He mice. Mammary gland DNA content on day 12 of lactation was significantly lower in SMS 201-995 treated mice than in the control. There were little differences between groups in mammary gland RNA content and litter growth on day 12 of lactation. That was associated with a slightly higher RNA/DNA ratio and a significant increase in food intake during lactation. These results indicate that inhibited mammary gland growth by GH suppression has little effect on lactation. The smaller mammary gland can compensate by increasing its secretory activity.

摘要

在初产C3H/He小鼠中研究了SMS 201-995对生长激素（GH）分泌的长期抑制作用对泌乳的影响。在泌乳第12天，经SMS 201-995处理的小鼠乳腺DNA含量显著低于对照组。在泌乳第12天，各组之间乳腺RNA含量和窝仔生长情况差异不大。这与泌乳期间略高的RNA/DNA比值以及食物摄入量的显著增加有关。这些结果表明，GH抑制引起的乳腺生长受抑制对泌乳影响不大。较小的乳腺可以通过增加其分泌活性来进行补偿。