Nagasawa H, Koshimizu U, Sakagami N
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
In Vivo. 1988 Mar-Apr;2(2):167-9.
The interaction between somatostatin (SMS) and high doses of oestrogen on mammary gland growth was examined in C3H/He virgin mice. Mammary gland growth was significantly suppressed by the subcutaneous implantation of pellets of oestradiol benzoate diluted to 1/1000 or 1/500 or by injection twice daily of 50ng SMS 201-995 between 25 and 55 days of age. However, the mammary gland growth of mice receiving SMS and oestrogen in combination was markedly stimulated compared to that of mice given the respective agents. These results indicate that the inhibitory effects of somatostatin and oestrogen on mammary growth were apparently counteracted by the treatment in combination.
在C3H/He处女小鼠中研究了生长抑素（SMS）与高剂量雌激素对乳腺生长的相互作用。在25至55日龄之间，通过皮下植入稀释至1/1000或1/500的苯甲酸雌二醇丸剂，或每日两次注射50ng SMS 201 - 995，乳腺生长受到显著抑制。然而，与给予相应药物的小鼠相比，联合接受SMS和雌激素的小鼠的乳腺生长受到明显刺激。这些结果表明，生长抑素和雌激素对乳腺生长的抑制作用在联合治疗时显然被抵消了。
