Terblanche J, Kahn D, Bornman P C, Werner D
Department of Surgery, University of Cape Town Medical School, South Africa.
Surgery. 1988 Jun;103(6):624-32.
Twenty-one patients with cholangiocarcinoma at the confluence of the main right and left hepatic ducts were referred to our professorial surgical unit between 1968 and 1982. All were evaluated, treated, and documented prospectively with follow-up to mid 1986. No lesion was deemed resectable. The U tube palliative bypass developed during the course of the study was used in 14 patients, and its role in treating high bile duct carcinoma was evaluated. Histologic confirmation of the diagnosis was obtained in 71% of patients. Seven patients received additional treatment with radical radiotherapy. The 30-day overall hospital mortality rate was 19%. The 1- and 2-year survival rates were 57% and 33%, respectively. The quality of survival was usually good. The need for centralized referral and treatment of these difficult patients is stressed. The case against radical resection for this lesion is presented. It is concluded that radical resection is seldom possible, and therefore the U tube palliative procedure is advocated in most patients.
1968年至1982年间,21例肝左右主胆管汇合处胆管癌患者被转诊至我们的外科教授团队。所有患者均接受了前瞻性评估、治疗并记录,随访至1986年年中。无一例病变被认为可切除。研究过程中开发的U形管姑息性旁路手术应用于14例患者,并评估了其在治疗高位胆管癌中的作用。71%的患者获得了组织学确诊。7例患者接受了根治性放疗的额外治疗。30天总住院死亡率为19%。1年和2年生存率分别为57%和33%。生存质量通常良好。强调了对这些疑难患者进行集中转诊和治疗的必要性。提出了反对对该病变进行根治性切除的理由。结论是根治性切除很少可行,因此主张对大多数患者采用U形管姑息性手术。