Artigas F, Martínez E, Camón L, Rodríguez Farré E
Department of Neurochemistry, C.S.I.C., Barcelona, Spain.
Toxicology. 1988 Apr;49(1):49-55. doi: 10.1016/0300-483x(88)90173-4.
We have developed a model for the treatment of data of concentration of brain neurotransmitters (particularly serotonin and the catecholamines), in which the changes induced by any given treatment on the neurotransmitter (NT) and its main metabolite (ME) are converted into 2 new parameters named S and U, that are related to the modifications in the synthesis (S) and utilization (U) of the neurotransmitter elicited by the treatment. Using this model we have studied the effect of subconvulsant doses of lindane and other hexachlorocyclohexane isomers (alpha, beta and delta) on brain monoaminergic systems. The results obtained indicate that serotonergic activity is increased in cell bodies (dorsal raphe) as well as in regions rich in nerve terminals after treatment with lindane. Also, the activity of dopaminergic neurons is increased in the substantia nigra. These results are in agreement with the proposed role of lindane as a "picrotoxinin-like" substance acting as an antagonist at the GABA-A receptor complex and thus impairing the inhibitory tone exerted by GABA on a variety of neurons (serotonin in raphe nuclei and dopamine in substantia nigra).
我们已经开发出一种用于处理大脑神经递质（特别是血清素和儿茶酚胺）浓度数据的模型。在该模型中，任何给定处理对神经递质（NT）及其主要代谢物（ME）所引起的变化被转换为两个新参数，即S和U，它们与该处理引发的神经递质合成（S）和利用（U）的改变有关。利用这个模型，我们研究了亚惊厥剂量的林丹及其他六氯环己烷异构体（α、β和δ）对大脑单胺能系统的影响。所获得的结果表明，在用林丹处理后，血清素能活性在细胞体（中缝背核）以及富含神经末梢的区域均有所增加。此外，黑质中多巴胺能神经元的活性也增加。这些结果与林丹作为一种“类似印防己毒素”的物质的作用相符，该物质在GABA - A受体复合物处作为拮抗剂起作用，从而削弱了GABA对多种神经元（中缝核中的血清素和黑质中的多巴胺）施加的抑制性张力。
