Camón L, Martínez E, Artigas F, Solà C, Rodríguez-Farré E
Department of Pharmacology and Toxicology, Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
Toxicology. 1988 May;49(2-3):389-94. doi: 10.1016/0300-483x(88)90023-6.
The effect of lindane (gamma-HCH) on temperature, food intake and body weight was studied in male and female rats after single or repeated non-convulsant oral doses. A single dose of 30 mg/kg induced a significant decrease of core temperature (0.4 degrees C in males and 0.66 degrees C in females) 5 h after administration when compared to the control value. Lindane-induced hypothermia was strongly potentiated (1.45 degrees C) by cold stress when rats were kept at 4 degrees C. The same dose of lindane produced a significant decrease in body weight gain (-85% in males and -219% in females compared to the control gain), accompanied by a diminution of food intake, 24 h after administration. No decrease in both parameters was observed when alpha- or delta-HCH isomers 30 mg/kg were tested. After daily administration with 10 mg/kg lindane for 7 days, no hypothermic effects were observed. However, a slight but significant decrease in body weight gain was recorded over the treatment period. This effect was also accompanied by a reduced food intake. The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses.
在雄性和雌性大鼠单次或重复给予非惊厥剂量的口服林丹（γ-六氯环己烷）后，研究了其对体温、食物摄入量和体重的影响。与对照值相比，给予30mg/kg的单次剂量后5小时，核心体温显著下降（雄性下降0.4℃，雌性下降0.66℃）。当大鼠置于4℃环境中时，冷应激会使林丹诱导的体温过低显著增强（1.45℃）。相同剂量的林丹在给药24小时后，体重增加显著下降（与对照增加量相比，雄性下降85%，雌性下降219%），同时食物摄入量减少。当测试30mg/kg的α-或δ-六氯环己烷异构体时，未观察到这两个参数的下降。在每天给予10mg/kg林丹，持续7天后，未观察到体温过低效应。然而，在治疗期间记录到体重增加略有但显著下降。这种效应也伴随着食物摄入量减少。观察到的六氯环己烷异构体对核心体温和体重的立体选择性效应可能是研究低惊厥剂量林丹神经毒性机制的有用模型。
