Warren K G, Catz I, Bauer C
Department of Medicine, University of Alberta, Edmonton, Canada.
Ann Neurol. 1988 Mar;23(3):297-9. doi: 10.1002/ana.410230314.
Free and bound levels of anti-myelin basic protein (anti-MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of 20 patients with acute idiopathic optic neuritis, 133 patients with multiple sclerosis (MS) divided into three clinical subgroups, and 76 normal control subjects. Patients with idiopathic optic neuritis had elevated levels of anti-MBP predominantly in free form, resulting in an elevated (above unity) free/bound anti-MBP ratio similar to that of MS patients with acute relapses. These data suggest that acute idiopathic optic neuritis, like active MS, is associated with anti-MBP.
采用放射免疫分析法测定了20例急性特发性视神经炎患者、133例分为三个临床亚组的多发性硬化症（MS）患者以及76名正常对照者脑脊液中抗髓鞘碱性蛋白（anti-MBP）抗体的游离和结合水平。特发性视神经炎患者的抗-MBP水平主要以游离形式升高，导致游离/结合抗-MBP比值升高（高于1），类似于急性复发的MS患者。这些数据表明，急性特发性视神经炎与活动期MS一样，与抗-MBP有关。
