Egerter D A, Beckstead J H
Department of Pathology, University of California, San Francisco 94143.
Arch Pathol Lab Med. 1988 Jun;112(6):602-6.
An increased incidence of high-grade malignant non-Hodgkin's lymphomas has been reported in homosexual men. This phenomenon appears to represent another facet of the acquired immunodeficiency syndrome (AIDS). Histologically, the majority of these lymphomas have been small noncleaved cell lymphomas or immunoblastic lymphomas, subtypes most commonly associated with a B-cell phenotype, but immunologic data supporting this have been limited. Using a plastic embedding technique, we have examined a series of 31 malignant lymphomas, including nine from the central nervous system (CNS), in patients with AIDS or at high risk for AIDS. All 31 of the lymphomas were positive with one or more of the following B-cell markers: HLA-DR/la, Pan B, Leu 12, Leu 14, and IgM. All 31 were negative for the pan-T reagent Leu 4 and myeloid-macrophage markers (Leu M1, nonspecific esterase). In addition, seven of the nine CNS lymphomas showed strong plasma membrane staining for adenosine triphosphatase, a B-associated marker. These findings provide strong immunologic evidence for a B-cell origin in the lymphomas of AIDS.
据报道，同性恋男性中高级别恶性非霍奇金淋巴瘤的发病率有所增加。这一现象似乎代表了获得性免疫缺陷综合征（艾滋病）的另一个方面。从组织学上看，这些淋巴瘤大多数为小无裂细胞淋巴瘤或免疫母细胞淋巴瘤，这些亚型最常与B细胞表型相关，但支持这一点的免疫学数据有限。我们采用塑料包埋技术，对31例艾滋病患者或艾滋病高危患者的恶性淋巴瘤进行了检查，其中包括9例中枢神经系统（CNS）淋巴瘤。所有31例淋巴瘤对以下一种或多种B细胞标志物呈阳性：HLA-DR/la、泛B、Leu 12、Leu 14和IgM。所有31例对泛T试剂Leu 4和髓样巨噬细胞标志物（Leu M1、非特异性酯酶）均为阴性。此外，9例中枢神经系统淋巴瘤中的7例显示出与B相关的标志物三磷酸腺苷酶的强质膜染色。这些发现为艾滋病淋巴瘤的B细胞起源提供了有力的免疫学证据。
