Andersson P O, Andersson K E, Fahrenkrug J, Mattiasson A, Sjögren C, Uvelius B
Department of Pharmacology, AB LEO, Helsingborg, Sweden.
J Urol. 1988 Jul;140(1):168-72. doi: 10.1016/s0022-5347(17)41520-5.
The concentrations of substance P and vasoactive intestinal polypeptide (VIP) were determined in the upper, middle, and lower part of the bladder of rats with and without infravesical outflow obstruction. In the obstructed animals there was a significant increase in bladder weight and the total amounts of substance P and VIP were increased. However, the concentrations of substance P were significantly lower than in the control bladders. The concentrations of VIP, on the other hand, were significantly higher in the middle and lower parts of obstructed bladders than in the controls. In isolated strips of the normal and obstructed bladders VIP had neither contractile nor relaxant effects. The peptide had no effect on electrically induced contractions. Substance P produced concentration-dependent contractions in both normal and obstructed bladders. However, obstructed bladders were significantly less sensitive than controls. It is concluded that the bladder instability seen in rats with infravesical outflow obstruction cannot be explained only in terms of changes in the bladder content of substance P or VIP.
测定了有或无膀胱流出道梗阻的大鼠膀胱上、中、下部分中P物质和血管活性肠肽（VIP）的浓度。在梗阻动物中，膀胱重量显著增加，P物质和VIP的总量增加。然而，P物质的浓度显著低于对照膀胱。另一方面，梗阻膀胱中、下部分VIP的浓度显著高于对照。在正常和梗阻膀胱的离体条带上，VIP既无收缩作用也无舒张作用。该肽对电诱导的收缩无作用。P物质在正常和梗阻膀胱中均产生浓度依赖性收缩。然而，梗阻膀胱的敏感性明显低于对照。得出的结论是，膀胱流出道梗阻大鼠中出现的膀胱不稳定不能仅用膀胱中P物质或VIP含量的变化来解释。
