Almay B G L, Johansson F, Von Knorring L, Le Grevés P, Terenius L
Department of Neurology, Umeå University, S-901 85 UmeåSweden Department of Psychiatry, Umeå University, S-901 85 UmeåSweden Department of Pharmacology, Uppsala University, S-751 24 UppsalaSweden.
Pain. 1988 Apr;33(1):3-9. doi: 10.1016/0304-3959(88)90197-2.
Immunoreactive substance P was determined in lumbar CSF of 35 healthy volunteers and 60 patients with chronic pain syndromes of at least 6 months duration. No significant relationships were found between substance P levels and age, sex or body height. Substance P levels were lower in chronic pain patients, with either neurogenic (n = 23) or idiopathic pain (n = 37) syndromes, than in the healthy volunteers. Substance P levels were especially low in patients with neurogenic pain with lesions involving the extremities and in those with polyneuropathy, while patients with central pain or pain of the head or face had higher values. Substance P levels were related to depressive symptomatology as determined by means of visual analogue scales and to stable personality traits as determined by means of the Karolinska Scales of Personality (KSP). The most consistent (and inverse) relationship was found between substance P levels and the symptom 'inner tension' and between substance P levels and the personality trait 'psychic anxiety.'
在35名健康志愿者和60名患有至少6个月慢性疼痛综合征的患者的腰椎脑脊液中测定了免疫反应性P物质。未发现P物质水平与年龄、性别或身高之间存在显著关系。患有神经源性（n = 23）或特发性疼痛（n = 37）综合征的慢性疼痛患者的P物质水平低于健康志愿者。涉及四肢病变的神经源性疼痛患者和患有多发性神经病的患者的P物质水平尤其低，而患有中枢性疼痛或头部或面部疼痛的患者的P物质水平较高。P物质水平与通过视觉模拟量表确定的抑郁症状以及通过卡罗林斯卡人格量表（KSP）确定的稳定人格特质相关。在P物质水平与“内心紧张”症状以及P物质水平与人格特质“精神焦虑”之间发现了最一致（且相反）的关系。
