Stjernswärd J
World Health Organization, Geneva, Switzerland.
Cancer Surv. 1988;7(1):195-208.
Cancer pain relief is a ubiquitous but neglected public health problem. Every day more than three and a half million people suffer from cancer pain, but only a fraction receive treatment for it. Relatively simple and inexpensive methods of pain relief are available. Adequate pain relief is not reaching a great number of cancer patients in developed countries. In the developing countries, where more than half the world's cancer patients are and where most are incurable at the time of diagnosis, pain relief (often the only relevant human alternative) by and large is not offered. Obstacles to effective cancer pain relief worldwide include poor drug availability, misguided national drug legislation, lack of education of doctors and nurses, underprescribing and underdosing by the professionals, wrong timing of drugs given, fear of addiction and lack of public awareness that pain can be controlled. A World Health Organization (WHO) method has been developed which provides for drugs to be administered immediately if there is pain, to be given 'by the clock' rather than 'on demand' and to be increased from non-opioids (aspirin or paracetamol) to weak opioids (codeine) and then to strong opioids (morphine) until the patient is free from pain--hence the concept of a three-step ladder for cancer pain relief. Field tests have shown that the right drug in the right dose at the right time relieves 80 to 90% of pain. Thus a scientifically valid, relatively inexpensive method suitable for reaching patients at community level does exist.
癌症疼痛缓解是一个普遍存在但却被忽视的公共卫生问题。每天有超过三百五十万人遭受癌症疼痛的折磨,但只有一小部分人接受了相关治疗。有相对简单且成本低廉的疼痛缓解方法。在发达国家,大量癌症患者并未得到充分的疼痛缓解治疗。在发展中国家,全球一半以上的癌症患者身处此地,且大多数患者在确诊时已无法治愈,然而大体上并未提供疼痛缓解治疗(这往往是唯一可行的人道选择)。全球有效缓解癌症疼痛的障碍包括药品供应不足、国家药品立法误导、医生和护士缺乏培训、专业人员处方不足和剂量不足、给药时间错误、担心成瘾以及公众缺乏疼痛可控制的意识。世界卫生组织(WHO)已制定出一种方法,即如果患者疼痛,应立即给药,按“钟点”给药而非“按需”给药,且药物应从非阿片类药物(阿司匹林或对乙酰氨基酚)逐步增至弱阿片类药物(可待因),然后再到强阿片类药物(吗啡),直至患者无痛——由此产生了癌症疼痛缓解的三步阶梯概念。现场试验表明,在正确的时间给予正确剂量的正确药物可缓解80%至90%的疼痛。因此,确实存在一种科学有效、相对廉价且适用于社区层面患者的方法。