Takeda F
Neurosurgery Clinic, Saitama Cancer Center.
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-1):1031-7.
Pain, the most frequent subjective symptom in cancer patients, can and must be treated. Satisfactory pain relief helps whatever patients achieve their remaining potential. This transforms his experience and the memories of his family. Management of pain becomes the physician's primary objective if there is no available treatment for the cause of pain. The use of analgesic drugs is the mainstay in cancer pain management. When used correctly, analgesics are effective in a high percentage of cancer patients. This approach can be implemented in all medical settings and serves to improve quality of life in far-advanced cancer patients. A three-step analgesic ladder indicating the sequential use of the drugs was proposed by the World Health Organization (WHO) in 1986. The three standard analgesics making up this ladder are aspirin (non-opioid), codeine (weak opioid) and morphine (strong opioid). In patients with mild pain, non-opioid drugs such as aspirin, acetaminophen, or any of the non-steroidal anti-inflammatory drugs will be adequate. In patients with moderate pain, if non-opioids do not provide adequate relief, codeine or an alternative weak opioid should be prescribed. In patients with severe pain, morphine, a strong opioid, is the drug of choice. A series of principles established on the basis of considerable clinical experience and of controlled studies of analgesics indicate that the dose of an analgesic should be determined on an individual basis, and administered on a regular basis by the clock.
疼痛是癌症患者最常见的主观症状,能够且必须得到治疗。令人满意的疼痛缓解有助于患者发挥剩余的潜能。这会改变患者自身及其家人的记忆。如果疼痛原因无法得到有效治疗,那么疼痛管理就成为医生的首要目标。使用镇痛药是癌症疼痛管理的主要手段。正确使用时,镇痛药对大部分癌症患者都有效。这种方法可在所有医疗环境中实施,有助于提高晚期癌症患者的生活质量。1986年,世界卫生组织(WHO)提出了一个三步镇痛阶梯方案,用以指导镇痛药的序贯使用。构成该阶梯的三种标准镇痛药分别是阿司匹林(非阿片类)、可待因(弱阿片类)和吗啡(强阿片类)。对于轻度疼痛患者,阿司匹林、对乙酰氨基酚或任何一种非甾体抗炎药等非阿片类药物就足够了。对于中度疼痛患者,如果非阿片类药物不能提供足够的缓解,应开具可待因或其他弱阿片类药物。对于重度疼痛患者,吗啡这种强阿片类药物是首选。基于大量临床经验和镇痛药对照研究确立的一系列原则表明,镇痛药的剂量应根据个体情况确定,并按时规律给药。