Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):388-91. doi: 10.1021/np400665a. Epub 2014 Feb 18.
Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)JHH values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.
从深海来源的链霉菌 SCSIO 03032 中改变培养条件后分离到三个新的大环内酯类化合物，即鹤酰胺 D-F（1-3）。通过广泛的 MS 和 NMR 光谱分析以及与密切相关的鹤酰胺 A-C 的比较，阐明了鹤酰胺 D-F（1-3）的平面结构。通过详细分析 3JHH 值和 NOESY 数据，推导出了 1-3 的相对构型。通过化学修饰和应用改进的 Mosher 法确定了 1 和 2 的绝对构型。这些化合物均没有明显的抗菌或细胞毒性活性。
