尼扎拉菌素 A-C，从含有分枝菌酸的分枝杆菌与链霉菌的混合培养物中分离得到的多环大环内酯类化合物。
Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium.
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033, Japan.
RIKEN Center for Life Science Technologies , 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
出版信息
J Nat Prod. 2015 Dec 24;78(12):3011-7. doi: 10.1021/acs.jnatprod.5b00804. Epub 2015 Dec 1.
A terrestrial bacterium, Streptomyces sp. NZ-6, produced niizalactams A-C (1-3), unprecedented di- and tricyclic macrolactams, by coculturing with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. Their complete structures, including absolute configurations, were elucidated on the basis of spectroscopic data and chemical derivatization. Their unique skeletons are proposed to be biosynthesized from a common 26-membered macrolactam intermediate by SN2 cyclization or an intramolecular Diels-Alder reaction.
一株陆生细菌，链霉菌属 NZ-6，通过与含有分枝菌酸的细菌 Tsukamurella pulmonis TP-B0596 共培养，产生了 niizalactams A-C（1-3），这是前所未有的二聚和三聚环大环内酯。基于光谱数据和化学衍生化，确定了它们的完整结构，包括绝对构型。它们独特的骨架被认为是通过 SN2 环化或分子内 Diels-Alder 反应，由一个共同的 26 元大环内酯中间体生物合成而来的。
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