Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033, Japan.
RIKEN Center for Life Science Technologies , 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
J Nat Prod. 2015 Dec 24;78(12):3011-7. doi: 10.1021/acs.jnatprod.5b00804. Epub 2015 Dec 1.
A terrestrial bacterium, Streptomyces sp. NZ-6, produced niizalactams A-C (1-3), unprecedented di- and tricyclic macrolactams, by coculturing with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. Their complete structures, including absolute configurations, were elucidated on the basis of spectroscopic data and chemical derivatization. Their unique skeletons are proposed to be biosynthesized from a common 26-membered macrolactam intermediate by SN2 cyclization or an intramolecular Diels-Alder reaction.
一株陆生细菌，链霉菌属 NZ-6，通过与含有分枝菌酸的细菌 Tsukamurella pulmonis TP-B0596 共培养，产生了 niizalactams A-C（1-3），这是前所未有的二聚和三聚环大环内酯。基于光谱数据和化学衍生化，确定了它们的完整结构，包括绝对构型。它们独特的骨架被认为是通过 SN2 环化或分子内 Diels-Alder 反应，由一个共同的 26 元大环内酯中间体生物合成而来的。
