Stapells D R, Galambos R, Costello J A, Makeig S
Children's Hospital Research Center, San Diego, CA 92123.
Electroencephalogr Clin Neurophysiol. 1988 Jul-Aug;71(4):289-95. doi: 10.1016/0168-5597(88)90029-9.
Auditory middle latency and steady-state responses (MLR/SSRs) were recorded in normal infants (aged 3 weeks to 28 months) and adults. SSR amplitudes were maximum using stimulus presentation rates near 40 Hz in adults. By contrast, the infant data showed no consistent amplitude maximum across the rates tested (9-59 Hz). With the exception of the brain-stem response wave V to MLR Na deflection, MLR components in infants' responses to 10.85 Hz clicks did not show any consistent pattern. To investigate the hypothesis that the 40 Hz SSR is derived from overlapping of the 10 Hz MLR components, 43.4 Hz SSRs were synthesized from the responses recorded at 10.85 Hz and compared with those recorded at 43.4 Hz. The predictive accuracy of the synthesized 43.4 Hz SSRs was significantly better in adults than in infants. The results of these studies indicate the presence of large age-related differences in the auditory MLR and SSR, and in the relationship between the two responses.
在正常婴儿（年龄3周至28个月）和成人中记录了听觉中潜伏期和稳态反应（MLR/SSR）。成人中，刺激呈现率接近40Hz时SSR振幅最大。相比之下，婴儿数据显示在所测试的频率（9 - 59Hz）范围内没有一致的最大振幅。除了脑干对MLR Na偏转的反应波V外，婴儿对10.85Hz滴答声反应中的MLR成分未显示出任何一致的模式。为了研究40Hz SSR源自10Hz MLR成分重叠的假设，从10.85Hz记录的反应中合成了43.4Hz SSR，并与43.4Hz记录的结果进行比较。合成的43.4Hz SSR在成人中的预测准确性明显优于婴儿。这些研究结果表明，听觉MLR和SSR以及两种反应之间的关系存在与年龄相关的巨大差异。
