Goren Andy, Salafia Antonio, McCoy John, Keene Sharon, Lotti Torello
Applied Biology, Irvine, California, USA; Department of Dermatology and Venereology, University of Rome "G.Marconi", Rome, Italy.
Dermatol Ther. 2014 Jul-Aug;27(4):195-7. doi: 10.1111/dth.12115. Epub 2014 Feb 18.
Numerous studies have demonstrated that natural sunlight therapy at the Dead Sea provides therapeutic efficacy for vitiligo patients on par with artificial broadband and narrowband ultraviolet B (UVB) phototherapy; however, similar treatments at locals at or above sea level fail due to the development of erythema prior to sufficient therapeutic dosage. We conducted a pilot study at sea level to assess the efficacy of a novel topical cream that selectively filters nontherapeutic wavelengths of UVB from natural sunlight and delivers treatment for acrofacial vitiligo. In our pilot study, after an average of 11 weeks of treatment, all patients in the treatment arm responded to therapy. In particular, 28% of the treatment group had 70% surface area repigmentation, 28% had 50% repigmentation, and 44% had 30-40% repigmentation. In contrast, only 10% of the patients in the placebo arm had 20% repigmentation. Our results demonstrate that the novel topical cream can provide a safe and effective alternative to artificial light phototherapy.
众多研究表明，死海的自然阳光疗法对白癜风患者具有治疗效果，可媲美人工宽带和窄带紫外线B（UVB）光疗；然而，在海平面或海平面以上地区进行类似治疗时，由于在达到足够治疗剂量之前就出现了红斑，治疗失败。我们在海平面进行了一项试点研究，以评估一种新型外用乳膏的疗效，该乳膏可选择性过滤自然阳光中UVB的非治疗性波长，并用于治疗肢端面部白癜风。在我们的试点研究中，平均治疗11周后，治疗组的所有患者均对治疗有反应。特别是，治疗组中28%的患者有70%的表面积复色，28%的患者有50%的复色，44%的患者有30 - 40%的复色。相比之下，安慰剂组中只有10%的患者有20%的复色。我们的结果表明，这种新型外用乳膏可为人工光疗提供一种安全有效的替代方法。
